Background. Observational data suggest that the fixed initial recommended tacrolimus (Tc) dosing (0.2mg/kg/day) results in\nsupratherapeutic drug levels in some patients during the early posttransplant period.The aim of the study was to analyze a wide\npanel of patient-related factors and their interactions which increase the risk for first Tc blood level > 15 ng/ml. Materials and\nMethods. We performed a retrospective analysis of 488 consecutive adult kidney transplant recipients who were initially treated\nwith triple immunosuppressive regimen containing tacrolimus twice daily. The analysis included the first assessment of Tc trough\nblood levels and several demographic, anthropometric, laboratory, and comedication data. Results.Themultiple logistic regression\nanalysis showed that age > 55 years, BMI > 24.6 kg/m2, blood hemoglobin concentration > 9.5 g/dl, and the presence of anti-HCV\nantibodies independently increased the risk for first Tc level > 15 ng/ml.The relative risk (RR) for first tacrolimus level > 15 ng/ml\nwas 1.88 (95% CI 1.35ââ?¬â??2.64,
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